MicrobiologyBiomedicine & PharmacotherapyPeer-reviewed
The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden
Darryl JY Han, Xiangyu Sui, Sakshi Agarwal…·Stefan H. Oehlers
The paper shows pyrimethamine, an FDA-approved drug, reduces vascular permeability and mycobacterial burden in a zebrafish infection model by inhibiting bacterial dihydrofolate reductase and restoring vascular barrier function.
3 citations