Paweł Lisowski

Mitochondrial genome editing reveals the impact of complex I heteroplasmic variants on human neurogenesis

This study edits mtDNA variants in human iPSCs to show that heteroplasmic complex I variants impair neuronal commitment.

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

Methylation genome wide profiling in lowly and highly efficient adipose somatic cell nuclear transfer in pigs

The paper performs genome-wide methylation profiling to identify differentially methylated regions in adipose stem cells with high and low cloning efficiency in pigs.

SURF1 mutations causative of Leigh syndrome impair human neurogenesis

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.