Marek Ladislav

Dizocilpine-derived K2060 exhibits enhanced blockage at NMDA receptors with impaired Mg2+ block and provides strong protection against audiogenic seizures

This study evaluates how impaired Mg2+ block at NMDA receptors affects the efficacy of K2060, memantine, and ketamine in protecting against audiogenic seizures.

The role of disulfide bonds in the GluN1 subunit in the early trafficking and functional properties of GluN1/GluN2 and GluN1/GluN3 NMDA receptors

This study investigates the role of disulfide bonds in the GluN1 subunit of NMDA receptors, showing their impact on trafficking and function, and introduces a method for synchronized release of NMDARs from the endoplasmic reticulum.

Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition

This paper develops a novel NMDA receptor open-channel blocker, K2060, showing improved efficacy and reversibility compared to existing drugs like memantine and dizocilpine.

Dizocilpine derivatives with neuroprotective effect lacking the psychomimetic side effects

This study develops novel NMDA receptor antagonists with neuroprotective effects and reduced psychomimetic side effects through structural modifications of MK-801.

Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunits

This study shows that structural changes in the ligand-binding domains of GluN1 and GluN2A subunits independently regulate early trafficking of NMDARs and that surface expression does not always correlate with agonist sensitivity.

Ventral posterolateral and ventral posteromedial thalamus neurons have distinct synaptic and cellular physiology

This study compares synaptic and intrinsic properties of VPL and VPM thalamus neurons in mice, finding functional differences in their excitatory and inhibitory inputs and firing behavior.

Synaptic and intrinsic mechanisms impair reticular thalamus and thalamocortical neuron function in a Dravet syndrome mouse model

This paper investigates how NaV1.1 haploinsufficiency affects thalamocortical circuit function in a Dravet syndrome mouse model, revealing input-specific synaptic and intrinsic changes in thalamic neurons.