This study generates a transcriptomic atlas of in vitro-derived mononuclear phagocytes to clarify the identity of moDCs and their in vivo counterparts.

bioRxiv · Oct 13, 2026 · PreprintImmunology

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Louise Gorline, Fillipe Luiz Rosa Do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vétillard, Aboubacar Sidiki K. Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, , Pierre Guermonprez

The paper demonstrates that delivering FLT3L with CXCL9 and CCL5 enhances cDC1 infiltration and antitumor immunity in mice and humanized models.

Nature Communications · Dec 30, 2025Peer-reviewedImmunology

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Clemence Ngo, Camille Pierini-Malosse, Khalissa Rahmani, Michael Valente, Nils Collinet, Gilles Bessou, Capucine Guerry, Manon Fabregue, Solene Mathieu, Sarah Sharkaoui, Sophie Mazzoli, Amandine Sansoni, Frédéric FIORE, Caroline Laprie, Lena Alexopoulou, , Elena Tomasello

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

Nature Immunology · Sep 29, 2025Peer-reviewedImmunology

Mast cells are not essential for pubertal mammary gland branching.

Simran S. Kapoor, Clara M. Munz, Jimmy Marsden, Cyril Carvalho, Holly Tinsley, Marlène Magalhaes Pinto, Bert Malengier‐Devlies, Solvig Becker, Guillaume Seuzaret, Katelyn Patatsos, Ramazan Akyol, Amy B. Pederson, Gillian J. Wilson, Marc Dalod, Rebecca Gentek

This study shows that mast cells are not essential for pubertal mammary gland branching in mice, using multiple genetic models.

European Journal of Immunology · Aug 1, 2025Peer-reviewedDevelopmental Biology