ImmunologyJCI InsightPeer-reviewed
Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment
Ryusuke Hatae, Keith Kyewalabye, Akane Yamamichi…·Hideho Okada
This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.