Author

Akane Yamamichi

University of California, San FranciscoORCID 0000-0002-8141-7339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hideho OkadaiD· 3 shared Takahide NejoiD· 3 shared Aishi Zhao· 2 shared Heather L. Benway· 2 shared Jianwen LuiD· 2 shared Marco GallusiD· 2 shared Pavlina ChuntovaiD· 2 shared Payal B. WatchmakeriD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Hideho OkadaORCID

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3 papers

Recent·Most cited

Ultrasound-mediated blood-brain barrier modulation enhances T-cell access but requires immune activation for effective CNS immunity

Marco Gallus, Akane Yamamichi, Victor Andrés Arrieta, Takahide Nejo, Lan Phùng, Atsuro Saijo, Pavlina Chuntova, Jianwen Lu, Su Myat Phyu, Heather L. Benway, Aishi Zhao, Kaori Okada, Payal B. Watchmaker, Jeffrey Haegelin, Senthilnath Lakshmanachetty, , Hideho Okada

This study shows that ultrasound-mediated BBB modulation alone does not generate effective CNS immunity, but combining it with systemic immune activation enhances T-cell responses and improves immunotherapy efficacy.

bioRxiv · Aug 19, 2026 · PreprintImmunology

Spike-in probe-enhanced single-cell RNA-seq reveals post-infusion transcriptomic remodeling of "prime-and-kill" synNotch-CAR-T cells

Takahide Nejo, Payal B. Watchmaker, Milos Simic, Akane Yamamichi, Senthilnath Lakshmanachetty, Aishi Zhao, Jianwen Lu, Marco Gallus, Heather L. Benway, Robert Zhu, Ricardo Almeida, Wendell A. Lim, Hideho Okada

This paper develops a spike-in probe-enhanced scRNA-seq method to track and profile synNotch-CAR-T cells in vivo, revealing tissue-specific activation and transcriptional states.

bioRxiv · Mar 29, 2026 · PreprintCancer Biology

IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma

Megan Montoya, S. A. Collins, Pavlina Chuntova, Trishna S. Patel, Takahide Nejo, Akane Yamamichi, Noriyuki Kasahara, Hideho Okada

This study shows that delivering IRF8 via retroviral vector reprograms myeloid cells in glioblastoma, enhancing anti-tumor immunity and reducing immunosuppression.

Neuro-Oncology · Aug 8, 2024Peer-reviewedImmunology