Author

Christopher L. Passaglia

University of South FloridaORCID 0000-0001-5902-9818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra Zamitalo-Pomares· 1 shared Arjun Singh YadawiD· 1 shared Carlos A. ToroiD· 1 shared Christina M. NicouiD· 1 shared Christopher N. RudzitisiD· 1 shared Christopher P. CardozoiD· 1 shared Darryl R. OverbyiD· 1 shared David KrižajiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPhysiology

Alexandra Zamitalo-Pomares

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3 papers

Recent·Most cited

Circadian IOP rhythm in rats is driven by neural signals from the brain

Alexandra Zamitalo-Pomares, Christopher L. Passaglia

This study shows that the circadian intraocular pressure (IOP) rhythm in rats is driven by sympathetic efferents from the superior cervical ganglion, not local oscillators or humoral signals.

bioRxiv · Oct 27, 2025 · PreprintPhysiology

Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling

Sarah N. Redmon, Oleg V. Yarishkin, Christopher N. Rudzitis, Mónika Lakk, Jacques Bertrand, Joseph M. Sherwood, Christina M. Nicou, Christopher L. Passaglia, Darryl R. Overby, David Križaj

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

bioRxiv · Aug 14, 2025 · PreprintPhysiology

Central Nervous System axonal regeneration by spatially targeted drug combinations

Mustafa M. Siddiq, Nicholas P. Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A. Toro, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher P. Cardozo, , Ravi Iyengar

This study identifies a four-drug combination that promotes axonal regeneration in the optic nerve of rats by targeting subcellular processes, leading to functional recovery.

Frontiers in Pharmacology · Sep 20, 2023Peer-reviewedNeuroscience