Jorge R. Oksenberg

Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis

Paired CSF and blood scRNA/TCR-seq in treatment-naive MS shows a small set of expanded, cytotoxic CSF-enriched CD8+ clonotypes, two of which recognize EBV epitopes.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge

MHConstructor provides a haplotype-informed, high-throughput pipeline for de novo MHC assembly from short read data, improving upon reference-based methods.

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

This study identifies causal variants, cells, genes, and drug targets for type 1 diabetes using large-scale genetic and functional genomic analyses.

MHC*IMP - Imputation of Alleles for Genes in the Major Histocompatibility Complex

MHC*IMP imputes alleles for MHC genes using a reference panel and SNP data, achieving high accuracy in allele prediction.