Author

Leslie A. Crews

University of California San DiegoORCID 0000-0003-0704-0067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Silvia VicenziiD· 2 shared Andrea Zoey LiuiD· 1 shared Ashni A. Vora· 1 shared Bernadette Anne Chua· 1 shared Carlo M. Ong· 1 shared Dorota Skowronska‐KrawczykiD· 1 shared Edward David Ball· 1 shared Eric J. BennettiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Silvia VicenziORCID

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2 papers

Recent·Most cited

Cancer BiologyBloodPeer-reviewedOct 20, 2025

The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia

Kentson Lam, Yoon Joon Kim, Evelyn L. Tan…·Robert A. J. Signer

This study shows that proteasome inhibitors are ineffective in AML due to activation of HSF1 and autophagy, and that combining autophagy and proteasome inhibition effectively kills AML cells.

9 citationstop 3%

humanproteomics

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Cell BiologyGeroSciencePeer-reviewedApr 15, 2025

Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development

Silvia Vicenzi, Fangyuan Gao, Parker Côté…·Leslie A. Crews

This study identifies ELOVL2 as a key lipid metabolism enzyme that regulates B cell progenitor development and immune aging in mice and humans.

6 citations

mousehuman

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