Na Sun

ProxiNet transfers spatially learned cellular proximity from spatial transcriptomics to dissociated single-cell transcriptomes, revealing tissue organization and age-related changes in Alzheimer's.

Pop-Corn predicts how genetic perturbations reshape cell-type composition in single-cell and spatial contexts without reconstructing gene expression.

Haruka identifies condition-specific and shared spatial domains across tissues and conditions using contrastive learning, demonstrating improved detection of spatially heterogeneous perturbation responses.

This study develops cEpiNets to connect Alzheimer's disease genetics to microglial inflammatory responses by integrating epigenomic data across contexts.

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

The paper identifies convergent signals that encode epigenetic memory of adaptive states in NK cells under dietary restriction, showing how these signals reduce DNA damage and enhance metabolic plasticity.

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

The paper shows that combining CSF1R inhibition with GENUS stimulation improves cognitive function in Alzheimer's mice by restoring neural circuitry and gene expression.

The paper identifies cell type-specific transcriptomic changes in 5XFAD mice that link BBB dysfunction and metabolic dysregulation to early AD pathogenesis.

This study uses barcoded rabies virus with single-cell and in situ sequencing to map synaptic connectivity in the mouse brain, distinguishing cortical cell types by their connectivity patterns.

The paper identifies BNIP3 upregulation in cancer cell subpopulations associated with increased fitness and proliferation using single-cell data and organoid models.

The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.

The paper investigates how genome plasticity and transcriptional organization enable metabolic resilience to nutrient limitation and fasting endurance.

This study characterizes human cerebrovascular cells in health and disease, identifying cell type-specific markers and revealing immune activation and BBB integrity loss in Huntington's disease.