Author

Sergio Sebastian Pineda

Broad InstituteORCID 0000-0002-8903-0550Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Manolis KellisiD· 4 shared Myriam HeimaniD· 4 shared Hyeseung LeeiD· 3 shared Julio C. ManteroiD· 2 shared A. MatsushimaiD· 1 shared Alicia M. DarnelliD· 1 shared Ann M. GraybieliD· 1 shared Björn OskarssoniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Manolis KellisORCID

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5 papers

Recent·Most cited

Scn4b Modulates Huntington's Disease Phenotype Severity in vivo

Suphinya Sathitloetsakun, Vanessa Farrell, Sergio Sebastian Pineda, Hyeseung Lee, Jung Hoon Shin, F. García, Raleigh M. Linville, M Kellis, Veronica A. Alvarez, Myriam Heiman

This study shows that Scn4b modulates Huntington's disease severity by affecting gene expression and neuronal function in mouse models.

bioRxiv · Mar 10, 2026 · PreprintNeuroscience

Sideroflexins enable mitochondrial transport and metabolism of neutral amino acids

Samuel Block, Fangtao Chi, Paul C. Rosen, Sergio Sebastian Pineda, Luise E. Veelken, Alicia M. Darnell, Keene L. Abbott, Izabella Agostinho Pena, Myriam Heiman, Ömer H. Yilmaz, Matthew G. Vander Heiden

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

bioRxiv · Jun 18, 2025 · PreprintBiochemistry

Multisensory gamma stimulation enhances adult neurogenesis and improvescognitive function in male mice with Down Syndrome

Rezaul Islam, Brennan Jackson, Maeesha Tasnim Naomi, Brooke Schatz, Noah Tan, Mitchell H. Murdock, Dong Shin Park, Daniela Rodrígues-Amorím, Xueqiao Jiang, Sergio Sebastian Pineda, Chinnakkaruppan Adaikkan, Vanesa S. Fernandez Avalos, Ute Geigenmüller, Rosalind Mott Firenze, M Kellis, , Li‐Huei Tsai

This study shows that multisensory gamma stimulation improves cognitive function and adult neurogenesis in Ts65Dn mice, a model of Down syndrome.

PLoS ONE · Apr 24, 2025Peer-reviewedNeuroscience

Single-cell profiling of the human primary motor cortex in ALS and FTLD

Sergio Sebastian Pineda, Hyeseung Lee, Brent E. Fitzwalter, Shahin Mohammadi, Luc Pregent, Mahammad Gardashli, Julio C. Mantero, Erica Engelberg-Cook, Mariely DeJesus‐Hernandez, Marka van Blitterswijk, Cyril P. Pottier, Rosa Rademakers, Björn Oskarsson, Jaimin S. Shah, Ronald Carl Petersen, , Manolis Kellis

The paper creates a single-cell atlas of the human primary motor cortex in ALS and FTLD, identifying transcriptional changes and molecular similarities between Betz cells and VENs.

Cell · Mar 22, 2024Peer-reviewedNeuroscience

Huntington's Disease Produces Multiplexed Transcriptional Vulnerabilities of StriatalD1-D2 and Striosome-Matrix Neurons

A. Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriaki Galani, Julio C. Mantero, M Kellis, Myriam Heiman, Ann M. Graybiel

The paper examines transcriptional changes in striatal neurons in Huntington's disease, finding that striosomal SPNs are most depleted and compartmental markers are dysregulated in both mouse models and human HD.

bioRxiv · Apr 25, 2022 · PreprintNeuroscience