Author

Iris H. Nelen

Ghent UniversityORCID 0000-0002-3382-8395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Ellen SandersiD· 2 shared Fanny De VloediD· 2 shared Kaat DurinckiD· 2 shared Lisa DepesteliD· 2 shared Alexander M.M. EggermontiD· 1 shared Angeline Praveena Enton Raj· 1 shared Anna A. SablinaiD· 1 shared Annelies Van HemelrykiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Ellen SandersORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

Iris H. Nelen, Soetkin Leys, Sarah-Lee Bekaert, Fanny De Vloed, Fien Martens, Ellen Sanders, Angeline Praveena Enton Raj, Annika Jeschke, Shunya Ohmura, Thomas G. P. Grünewald, Liselot M. Mus, Tim Lammens, Nadine Van Roy, Bram De Wilde, Frank Speleman, , Kaat Durinck

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

Cell Death and Disease · Feb 25, 2026Peer-reviewedCancer Biology

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

C. Nunes, S.-L. Bekaert, S. Parsa, Iris H. Nelen, F. Martens, Elisa de Stanchina, Ellen Sanders, Elien Hilgert, Sara T’Sas, P. Zhao, Fanny De Vloed, Alexander M.M. Eggermont, Steven Goossens, Anna A. Sablina, Lisa Depestel, , Kaat Durinck

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

bioRxiv · Aug 29, 2024 · PreprintCancer Biology