Author

Sarah-Lee Bekaert

Ghent UniversityORCID 0000-0002-4769-3460Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:benchmark study· 1

Frequent Co-Authors

Frank SpelemaniD· 3 shared Ellen SandersiD· 2 shared Kaat DurinckiD· 2 shared Angeline Praveena Enton Raj· 1 shared Annelies Van HemelrykiD· 1 shared Annika Jeschke· 1 shared Arne ClaeysiD· 1 shared Bengt HallbergiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

Frank SpelemanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologyNature BiotechnologyPeer-reviewedMay 15, 2026

Widespread DNA off-targeting confounds studies of RNA chromatin occupancy

Micah Jonathan Goldrich, Louis Delhaye, Sarah-Lee Bekaert…·Igor Ulitsky

The paper shows that many reported RNA-chromatin interactions are technical artifacts caused by DNA off-targeting, not true biological interactions.

3 citationstop 2%

𝕏 PostBluesky

Cancer BiologyiSciencePeer-reviewedMar 5, 2026

RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma.

Joachim Tetteh Siaw, Arne Claeys, Wei‐Yun Lai…·Jimmy Van den Eynden

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

DOI 10.1016/j.isci.2026.115236

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Cancer BiologyCell Death and DiseasePeer-reviewedFeb 25, 2026

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

Iris H. Nelen, Soetkin Leys, Sarah-Lee Bekaert…·Kaat Durinck

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

3 citationstop 2%

humanbulk RNA-seq

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