Ellen Sanders

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.