Xufang Ru

The paper uses spatial transcriptome analysis in a mouse model of intraventricular haemorrhage to identify 3D gene expression trajectories and neural circuits involved in secondary brain injury.

This study shows that inhibiting Lipocalin-2 and Early Growth Response Protein 1 promotes oligodendrocyte differentiation and remyelination after white matter injury.

This paper investigates the opposing yet coordinated roles of Nrf1 and Nrf2 in response to tunicamycin-induced ER stress, showing how they regulate gene expression and maintain cellular homeostasis.

The paper investigates how different Nrf1 isoforms regulate distinct subsets of target genes, showing that Nrf1{gamma} acts as a dominant-negative competitor to Nrf1/{beta}.

This study shows that Nrf1 knockout leads to Nrf2 hyperactivation, promoting hepatoma, and reveals a feedback loop between Nrf1 and Nrf2 in tumor suppression.