Asta Zane

Stage-Specific NF-κB RelA and IRF4 Programs Drive -Synuclein-Induced Disease-Associated Microglia Differentiation

This study identifies NF-κB RelA and IRF4 as stage-specific regulators driving -synuclein-induced disease-associated microglia differentiation in Parkinson disease.

Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.

Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

This study identifies border-associated macrophages (BAMs) as key mediators of alpha-synuclein-induced neuroinflammation in Parkinson's disease.

IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

This study shows that IFNγ from CD4+ T cells drives neuroinflammation and demyelination in a mouse model of MSA.