Lisa Z. Fang

This study shows early-life stress alters chromatin modifications in the VTA, increasing stress sensitivity through changes in histone dynamics and Setd7 activity.

This study shows that increased H3K4me1 in the nucleus accumbens during early life primes lifelong stress sensitivity by altering chromatin structure and neuronal function.

This study identifies ventral pallidal GABAergic neurons as a key population controlling hedonic feeding and obesity in mice through optogenetic and ablation experiments.

This study shows that requiring mice to perform a simple action to access high-fat diet reduces intake and prevents obesity, suggesting that easy access promotes overeating.

The paper defines the transcriptional taxonomy of ventral pallidum cell types across mice, macaques, and baboons using snRNA-seq and in situ hybridization, finding transcriptional conservation and unique subclusters in primates.

This study shows that GluN3A persistence in the adult ventral hippocampus reduces glutamate release and NMDAR-dependent long-term potentiation, impacting emotional processing.