Matthew P. Parsons

This study shows that loss of wild-type huntingtin in adult striatal neurons reduces excitability and causes neuroinflammation without affecting tissue structure or motor behavior.

This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.

This study shows that wild-type huntingtin (wtHTT) is essential for synaptic plasticity in the adult hippocampus, as its loss impairs long-term potentiation and post-tetanic potentiation.

This study shows that GluN3A persistence in the adult ventral hippocampus reduces glutamate release and NMDAR-dependent long-term potentiation, impacting emotional processing.

The paper shows that GLT-1 dysfunction disproportionately affects presynaptic glutamate clearance in an Alzheimer's mouse model, highlighting presynaptic vulnerability.