Daniel Shriner

The paper analyzes genetic diversity in the All of Us Research Program, showing that self-identified race and ethnicity groups exhibit continuous genetic variation rather than discrete clusters, with implications for genetic association studies.

The paper uses random forest classifiers trained on simulated data to accurately genotype structural variants in the alpha globin region, outperforming existing software in ancestry-specific allele frequency estimation.

The paper identifies KTD1 as a novel defense factor in Saccharomyces cerevisiae that confers resistance to the K28 killer toxin.

This paper conducts a GWAS in Africans to identify novel lipid loci and finds 23 novel associations, with some replicating in African Americans and additional loci emerging from meta-analysis.

This study evaluates genetic risk scores for cardiometabolic traits in sub-Saharan Africans, African Americans, and European Americans, finding significantly lower predictive utility in sub-Saharan Africans.

This paper compares alignment-based and assembly-based variant calling in Africans, finding that assembly-based methods detect more clinically relevant variants and reveal biases in existing reference databases.

The paper identifies a novel type 2 diabetes locus, ZRANB3, in sub-Saharan Africans and shows its potential role in beta cell proliferation through zebrafish studies.

This study reanalyzes ancient Eurasian DNA data using a broader reference panel, revealing greater ancestral heterogeneity and new insights into population movements and ancestry transitions.

The paper uses whole genome sequence data to trace the origin of the sickle allele to the Holocene Wet Phase, showing a single origin and simplifying haplotype classification.