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The paper presents GAIA, a global atlas of immune alleles, showing that underrepresented groups have more diverse alleles needed for vaccine design than Northwest European groups.

This paper shows that trustworthy agentic genome interpretation requires executing validated skills as code rather than relying on models to reason or retrieve information, ensuring deterministic and auditable results.

This study links plasma proteome data to genetics in Ugandan individuals, identifying novel pQTLs and proteins causally associated with type 2 diabetes.

The paper introduces two fine-mapping methods to account for ancestral and environmental heterogeneity in GWAS, improving resolution of causal variants across diverse populations.

This study identifies three SNPs suggestively associated with MDD in Ugandan HIV-positive adults, highlighting potential genetic links to psychiatric conditions.

This paper introduces env-MR-MEGA, a meta-regression model that adjusts for environmental and ancestral heterogeneity in GWAS meta-analysis, improving association power.

This paper introduces MGflashfm and MGfm, methods that improve fine-mapping resolution by integrating multiple traits and population groups using summary statistics.

This study sequenced whole genomes of 449 Nigerian individuals from 47 ethnolinguistic groups to catalog genetic diversity and identify novel and medically relevant variation.

This study identifies genetic variants associated with smoking initiation and cessation in men of African ancestry, highlighting underrepresented populations in genetic research.

The Uganda Genome Resource provides a genomic database for studying disease susceptibility and risk factors in Ugandan populations, with applications in discovering genetic loci, refining associations, and developing polygenic risk scores.

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

This study investigates the interaction of the Omicron SARS-CoV-2 spike RBD with ACE2 and a neutralizing mAb, finding enhanced ACE2 binding and reduced mAb binding efficiency.

This study conducts the first GWAS of eGFR in Africans, identifies two genome-wide significant loci, and highlights the need for more African-specific genetic research on kidney function.

This study evaluates if African American or multi-ethnic polygenic risk scores improve type 2 diabetes prediction in continental Africans, finding that African American-derived scores are more predictive.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.