Author

Hazyadee Frecia Rodríguez-Gutiérrez

Centre National de la Recherche ScientifiqueORCID 0000-0001-5764-4243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Anne-Laure IscacheiD· 2 shared Roxana KhazeniD· 2 shared Sabina MülleriD· 2 shared Salvatore ValituttiiD· 2 shared Alejandro Vanazzi· 1 shared Ashwin JainarayananiD· 1 shared Aurélie MontagneiD· 1 shared Béatrice CorreiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Anne-Laure IscacheORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 18, 2026

Sustained antigenic engagement programs multidimensional CTL states with distinct cytotoxic capacities

Hazyadee Frecia Rodríguez-Gutiérrez, Ashwin Jainarayanan, Marie Tosolini…·Roxana Khazen

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

DOI 10.64898/2026.10.12.758563

humanscRNA-seq

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ImmunologybioRxivPreprintOct 16, 2026

Selective granzyme B replenishment dominates the molecular switch for sustained cytotoxicity in effector CD8+ T lymphocytes

Hazyadee Frecia Rodríguez-Gutiérrez, Anne-Laure Iscache, Aurélie Montagne…·Roxana Khazen

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

DOI 10.64898/2026.10.09.758067

humanexperimental assay

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