Salvatore Valitutti

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

The paper describes stenocytosis, a mechanism by which CTLs transfer supramolecular attack particles into target cells through narrow actin gaps.

The paper introduces IVEA, a deep-learning platform for automated exocytosis analysis in live-cell imaging, which is faster and more reliable than manual methods.

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

This study shows that Polo-like kinase 1 (PLK1) is essential for immune synapse (IS) assembly and cytotoxic T cell function by regulating microtubule dynamics during IS formation.

The paper introduces a methodology and web platform called ISiCell to improve collaboration between biologists and modelers in creating agent-based models for cell biology.