Adriaan B. Houtsmuller

This study investigates how XPG function is regulated during nucleotide excision repair through dynamic interactions with TFIIH, XPA, and EXO1, revealing mechanisms of XPG recruitment and dissociation from DNA damage.

The paper identifies a minimum threshold for myelination of pyramidal neurons' axons in human and mouse neocortex based on axonal calibre and interbranch distance.

This study identifies PAXIP1 and STAG2 as co-regulators of the Glucocorticoid Receptor (GR) that maintain 3D genome architecture and enable stress hormone-dependent transcription.

This study uses multi-color dSTORM microscopy to analyze RAD51 and DMC1 organization at meiotic DSBs in Hormad1-/- mice, revealing altered recombinase configurations and synaptonemal complex structure.

The paper shows RNA polymerase II is necessary for spatial chromatin reorganization after mitosis, as demonstrated by Hi-C and in silico modeling.

The paper investigates the development of the calyx of Held synapse in vivo, finding that only one synaptic input strengthens to calyceal levels, correlating with the largest VGluT cluster, and not indicating a structure-function mismatch.

The paper uses super-resolution microscopy to analyze RAD51 and DMC1 distribution at meiotic DSB repair foci in mouse spermatocytes, revealing dynamic spatial configurations and their temporal changes.