Bart P. F. Rutten

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

The paper examines the associations of APOE ε2/ε4 dosage and lifestyle on neuroimaging markers in the UK Biobank, finding no significant interaction between lifestyle and APOE dosage.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

The paper replicates an antidepressant response polygenic risk score (PRS-AR) in an independent trial and shows drug-specific effects and improved remission rates with stratification.

The paper applies rTMS to SH-SY5Y cells to study its effects on neural activity using live calcium imaging, finding opposing effects of iTBS and cTBS on depolarization response.

This study examines whether cannabis use extent predicts psychotic-like and euphoric intoxication experiences in First Episode Psychosis patients and controls, finding a significant interaction between caseness and use frequency.

The paper investigates the relationship between jumping to conclusions bias, IQ, psychosis, and polygenic risk scores in a case-control study, finding that IQ significantly predicts JTC bias while schizophrenia PRS does not.

This study identifies DNA methylation changes in blood samples from psychosis patients, including treatment-resistant schizophrenia, and links them to biological age, smoking, and cellular composition.

The paper investigates how polygenic risk for schizophrenia interacts with childhood adversity to influence emotional dysregulation and psychosis proneness in adolescents and young adults.

The paper performs a meta-analysis of DNA methylation data from military cohorts to identify CpG sites and regions associated with PTSD development.

The paper examines the independent and combined effects of schizophrenia polygenic risk score and heavy cannabis use on psychotic disorder risk using EUGEI data, finding both factors independently increase risk.

The paper identifies mir-135b-5p as a regulator of persistent stress-enhanced memory and a potential therapeutic target and biomarker for PTSD.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.