A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
Albert Higgins‐Chen, Kyra Thrush, Yunzhang Wang, Christopher J. Minteer, Pei‐Lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, Ann Zenobia Moore, Stefania Bandinelli, Christiaan H. Vinkers, Eric H. G. J. M. Vermetten, Bart P. F. Rutten, Elbert Geuze, , Morgan E. Levine
This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.
Nature Aging · Jul 15, 2022Peer-reviewedBioinformatics