Megan R. McMullen

This study integrates multi-omics data from alcohol-fed mice to reveal metabolic and epigenetic changes in early alcohol-associated liver disease, highlighting a shift toward antioxidant responses.

This study identifies N-acyl amides from gut microbes as regulators of postprandial metabolic homeostasis by affecting host hormones, gene expression, and microbiome composition.

This study shows that preventing microglial reactivity protects against acute and progressive neurological dysfunction and motor impairments caused by alcohol abuse in mice.

The paper identifies a novel TGFβ-mt-dsRNA-stress granule axis that promotes IRF3-mediated fibrotic responses in hepatic stellate cells.

The paper uses Hi-C and scRNA-seq to analyze chromatin structure and gene expression in monocytes from alcohol-associated hepatitis patients, finding altered genome organization affecting immune gene expression.

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.