Srinivasan Dasarathy

The paper identifies complement biomarkers in urine linked to alcohol-associated liver disease and provides insights into liver-kidney crosstalk mechanisms.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

The paper uses Hi-C and scRNA-seq to analyze chromatin structure and gene expression in monocytes from alcohol-associated hepatitis patients, finding altered genome organization affecting immune gene expression.

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.