Daniel J. Cohen

A CRISPRi migration screen in neutrophil-like HL-60 cells identified Galvanin (TMEM154), a single-pass membrane protein whose negatively charged ectodomain electrophoreses anodally to steer cathodal electrotaxis.

This study shows electric fields modulate keratocyte migration speed and alignment without changing turning dynamics.

The paper demonstrates that local stimulation of cell migration in tissues can drive collective motion through cell-cell adhesion, accelerating healing and growth by 5-fold.

SCHEPHERD is a universal electrobioreactor platform that enables high-throughput, high-resolution, and programmable DC bioelectric stimulation to study cell behavior and tissue dynamics.

This study uses light-controlled EGF receptors to precisely manipulate tissue movements in epithelial cells, showing light can drive millimeter-scale rearrangements.

The paper introduces a robotic system for automated tissue scratching to study cell migration and healing, improving reproducibility and throughput.

This study uses a continuum mechanics framework to show that epithelial tissues regulate energy expenditure to maintain efficient migration, and demonstrates this through electrotaxis experiments.

This study develops a continuum model to explain spatial velocity heterogeneity in collective electrotaxis and applies it to design electric field protocols for controlled tissue migration.

This paper uses deep attention networks to learn collective migration rules from cell trajectory data across different tissue types, revealing distinct attention patterns for epithelial, endothelial, and metastatic cancer cells.