Thorsten Boroviak

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

This study generates marmoset PGCLCs from iPSCs using mRNA transfection and shows their differentiation into gonocyte-like cells in xenoreconstituted testes.

The paper investigates human primordial germ cell specification using in vitro models and in vivo datasets, revealing the role of TFAP2A and TFAP2C in PGC fate and amnion development.

The paper shows STAT3 and TFCP2L1 are essential for epiblast self-renewal during diapause, but only TFCP2L1 is needed for deriving embryonic stem cells in vitro.

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.

This study shows that STAT3 phosphorylation variants regulate naïve pluripotency and developmental timing in mouse embryos, with loss of active STAT3 causing developmental delay and metabolic defects.

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.

This study compares single-cell transcriptomes of human, marmoset, and mouse embryos to identify conserved and divergent features of preimplantation development.

Reanalysis of three human embryo scRNA-seq datasets resolves cell-type ambiguities, defines epiblast and primitive endoderm prototypes, and identifies t2iLGö and 5i/L/A naïve stem cells as epiblast-like.