M. Azim Surani

The paper maps X-linked gene reactivation and epigenetic silencing in developing PGCs, showing partial resistance to reactivation and enrichment of repressive marks.

The paper investigates human primordial germ cell specification using in vitro models and in vivo datasets, revealing the role of TFAP2A and TFAP2C in PGC fate and amnion development.

This study investigates epigenetic reprogramming in pig primordial germ cells, identifying similarities with human germline processes and potential for transgenerational epigenetic inheritance.

The paper identifies transposable elements resistant to epigenetic resetting in human germline cells and links them to developmental traits and diseases.

This study shows PRDM14 is essential for human PGC fate, contradicting previous findings, and reveals divergent regulatory mechanisms between human and mouse PGCs using inducible degrons.

The paper analyzes pig embryos at single-cell resolution to study lineage segregation, pluripotency, and X-chromosome inactivation during early development, revealing conserved mechanisms with human embryos.

This paper develops a Bayesian pseudotime method to model transcriptional branching in human embryos and identifies regulators of PGC specification.

This study identifies key regulators of the transition from pluripotency to germ cell fate using CRISPR screening in PGC-like cells, highlighting Nr5a2 and Zfp296 as critical factors.

This paper introduces branch-recombinant Gaussian processes (B-RGPs) to analyze branching and recombination in biological time series, demonstrating their application to gene expression data in Arabidopsis thaliana.

The paper investigates X-linked gene reactivation in mouse inner cell mass by analyzing epigenetic marks and transcription factors, finding differential reactivation speeds and mechanisms.