Susanne Bornelöv

This study analyzes the evolutionary patterns of Gypsy-family LTR retrotransposons across 249 Drosophila genomes, revealing shifts in regulatory mechanisms and transcription factor involvement.

The paper trains a deep learning model on yeast promoter sequences to predict gene expression and identifies cis-regulatory elements using explainable AI.

This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.

The paper evaluates and optimizes sequence-based gene regulatory deep learning models using a DREAM Challenge dataset, showing improvements through architectural and training strategy refinements.

FlaHMM automates the identification of piRNA clusters in Drosophila species using hidden Markov models and genome sequence data alone.

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

The paper identifies five additional flam-like piRNA clusters across 119 Drosophila species, showing conserved transposon silencing mechanisms in somatic ovarian cells.

The paper identifies a conserved stop codon enrichment at the 5' ends of mammalian piRNAs, revealing Zuc-dependent cleavage preferences and a potential link to translational machinery.

This study maps in vitro megakaryocyte progenitor states to their in vivo counterparts and identifies surface markers for their purification.

This study identifies LC8/Cut-up as an essential component of the PICTS complex in Drosophila, showing its role in transposon silencing through complex dimerisation.

The paper identifies NSUN6 as a methyltransferase that specifically targets mRNA 3UTR regions with the CTCCA motif, affecting translation termination but not essential for mouse development.

R.ROSETTA is an interpretable machine learning framework that identifies biological semantics from omics data, revealing potential gene interdependencies in autism case-control studies.

This study shows the NuRD complex regulates enhancer chromatin structure and Mediator access to control transcription during lineage commitment in ES cells.