This study shows PRDM14 is essential for human PGC fate, contradicting previous findings, and reveals divergent regulatory mechanisms between human and mouse PGCs using inducible degrons.

Nature Communications · Mar 9, 2020Peer-reviewedDevelopmental Biology

Bayesian inference of transcriptional branching identifies regulators of early germ cell development in humans

Christopher A. Penfold, Anastasiya Sybirna, John E. Reid, Aracely Castillo-Venzor, Elena Drousioti, Yun Huang, Murray Grant, Lorenz Wernisch, Zoubin Ghahramani A, M. Azim Surani

This paper develops a Bayesian pseudotime method to model transcriptional branching in human embryos and identifies regulators of PGC specification.

bioRxiv · Oct 15, 2018 · PreprintDevelopmental Biology

Branch-recombinant Gaussian processes for analysis of perturbations in biological time series

Christopher A. Penfold, Anastasiya Sybirna, John E. Reid, Yun Huang, Lorenz Wernisch, Zoubin Ghahramani A, Murray Grant, M. Azim Surani

This paper introduces branch-recombinant Gaussian processes (B-RGPs) to analyze branching and recombination in biological time series, demonstrating their application to gene expression data in Arabidopsis thaliana.

Bioinformatics · Jul 5, 2018Peer-reviewedBioinformatics