Author

Kevin Messacar

Children's Hospital ColoradoORCID 0000-0001-5830-3491Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:benchmarking· 2 Organism:human· 2 Assay:metagenomics· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Samuel R. DomingueziD· 2 shared Scot FedermaniD· 2 shared Alexander L Greninger· 1 shared Alicen Burns SpauldingiD· 1 shared Amy R. Henry· 1 shared Becky Fung· 1 shared Bette K Klenschmidt-DeMasters· 1 shared Bob C. LiniD· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Samuel R. DominguezORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 17, 2026

Vaccine imprinting drives increased SARS-CoV-2 variant infection in children

Timothy S. Johnston, Rahul Subramanian, Wakinyan Benhamou…·Daniel C. Douek

The paper shows that vaccine imprinting influences susceptibility to SARS-CoV-2 variants in children by linking immune history, antibody neutralization, and infection risk.

DOI 10.64898/2026.08.12.739589

humanproteomics

𝕏 PostBluesky

GenomicsGenome ResearchPeer-reviewedMay 1, 2019

Laboratory Validation of a Clinical Metagenomic Sequencing Assay for Pathogen Detection in Cerebrospinal Fluid

Steve A. Miller, Samia N. Naccache, Erik Samayoa…·Charles Y. Chiu

The paper validates a clinical metagenomic sequencing assay for detecting pathogens in cerebrospinal fluid, showing 73% sensitivity and 99% specificity compared to clinical tests.

583 citations

humanmetagenomics

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GenomicsGenome MedicinePeer-reviewedDec 1, 2015

Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the critical need for reference strain sequencing

Alexander L Greninger, Kevin Messacar, Thelma Dunnebacke-Dixon…·Charles Y Chiu

The paper reports the first draft genome assembly of Balamuthia mandrillaris from a PAM survivor and highlights the need for reference genomes in metagenomic diagnosis.

DOI 10.1186/s13073-015-0235-2

metagenomicsexperimental assay

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