Author

Steve A. Miller

University of California, San FranciscoORCID 0000-0002-9188-3392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:virus· 1

Frequent Co-Authors

Charles Y. ChiuiD· 3 shared Joseph L. DeRisiiD· 3 shared Charles LangelieriD· 2 shared Emily D. CrawfordiD· 2 shared Katrina KalantariD· 2 shared Matt S. ZinteriD· 2 shared Michael R. WilsoniD· 2 shared Stephanie A. ChristensoniD· 2 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenomics

Charles Y. ChiuORCID

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Author profile →

4 papers

Recent·Most cited

Identification of a polymorphism in the N gene of SARS-CoV-2 that adversely impacts detection by a widely-used RT-PCR assay

Manu Vanaerschot, Sabrina A Mann, James T. Webber, Jack Kamm, Sidney M. Bell, John Bell, Si Noon Hong, Minh Phuong Nguyen, Lienna Y. Chan, Karan D. Bhatt, Michelle Tan, Angela M. Detweiler, Alex Espinosa, Wesley C. H. Wu, Joshua Batson, , Emily D. Crawford

The paper identifies a SARS-CoV-2 N gene polymorphism that reduces RT-PCR assay sensitivity and emphasizes the need for multi-target testing.

bioRxiv · Aug 25, 2020 · PreprintMolecular Biology

Laboratory Validation of a Clinical Metagenomic Sequencing Assay for Pathogen Detection in Cerebrospinal Fluid

Steve A. Miller, Samia N. Naccache, Erik Samayoa, Kevin Messacar, Shaun Arevalo, Scot Federman, Doug Stryke, E Pham, Becky Fung, William J. Bolosky, Danielle Ingebrigtsen, Walter Lorizio, Sandra M. Paff, John A. D. Leake, Rick L. Pesano, , Charles Y. Chiu

The paper validates a clinical metagenomic sequencing assay for detecting pathogens in cerebrospinal fluid, showing 73% sensitivity and 99% specificity compared to clinical tests.

Genome Research · May 1, 2019Peer-reviewedGenomics

Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill Adults

Charles Langelier, Katrina Kalantar, Farzad Moazed, Michael R. Wilson, Emily D. Crawford, Thomas J. Deiss, Annika Belzer, Samaneh Bolourchi, Saharai Caldera, Monica Fung, Alejandra Jauregui, Katherine B. Malcolm, Amy Lyden, Lillian M. Khan, Kathryn Vessel, , Joseph L. DeRisi

This paper develops a metagenomic sequencing approach to diagnose lower respiratory tract infections by integrating pathogen detection, microbiome analysis, and host transcriptome data.

Proceedings of the National Academy of Sciences · Nov 27, 2018Peer-reviewedGenomics

Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients

Charles Langelier, Matt S. Zinter, Katrina Kalantar, Gregory Anthony Yanik, Stephanie A. Christenson, Brian D. O’Donovan, Corin V. White, Michael R. Wilson, Anil Sapru, Christopher C. Dvorak, Steve A. Miller, Charles Y. Chiu, Joseph L. DeRisi

This study uses metagenomic sequencing to detect respiratory pathogens in hematopoietic transplant patients, finding it more sensitive than conventional methods and identifying new pathogens.

American Journal of Respiratory and Critical Care Medicine · Jul 7, 2017Peer-reviewedGenomics