Christopher M. Overall

This study shows that SARS-CoV-2 3CLpro protease inactivates specific interferons by cleaving glycosylated variants, but interferon redundancy maintains antiviral activity.

This study identifies YibN as a functional interactor of YidC, showing it enhances membrane protein insertion and lipid production in bacteria.

DIPPER provides a spatiotemporal proteomics atlas of human intervertebral discs, revealing region-specific regulatory profiles and a hydration matrisome linked to MRI intensity.

The paper updates the HPP MS Data Interpretation Guidelines to improve accuracy and address new workflows and data standards.