Swathi Yadlapalli

The paper identifies P-body sequestration of clock transcripts as a mechanism delaying repressor synthesis, which sets the circadian period in Drosophila.

This study shows PFOA exposure accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism, leading to increased sensitivity to environmental stress.

This study measures metabolic heat output of individual Drosophila brains to examine effects of sex, genotype, age, and disease on brain metabolism.

This paper identifies MOR-containing SWI/SNF foci as perinuclear scaffolds that gate chromatin accessibility for circadian gene regulation, revealing a spatial mechanism for converting protein oscillations into transcriptional rhythms.

The paper investigates how spatial organization of clock proteins and chromatin regulates circadian gene repression in Drosophila.

The paper identifies an intron in the Drosophila timeless gene that acts as an RNA-based timer regulating circadian period length through nuclear retention of mRNA.

This study shows that chromatin accessibility oscillates with the circadian cycle in Drosophila clock neurons, with distinct motifs associated with dusk and dawn accessibility, and that Period protein is essential for these rhythms.

This paper describes a one-step CRISPR-based method for endogenous gene tagging in Drosophila melanogaster, enabling efficient screening and characterization of engineered lines without a visible eye marker.

This study shows clock proteins form dynamic nuclear foci that organize clock genes at the nuclear envelope to control circadian rhythms.