Siân C. Allerton

The paper tracks mitochondrial gene expression in live neurons using nanotweezers and finds downregulation of MT-ND1 and MT-ATP6 after exposure to α-synuclein aggregates.

This study investigates how N-terminal truncation and surface wetting influence α-synuclein condensate maturation and suggests a mechanism linking surface interactions to toxic aggregate formation.

This study uses molecular rotors to detect and compare oligomer formation and conversion to amyloids in wild-type and two α-synuclein variants, revealing differences in aggregation kinetics.