Author

Uwe Beffert

Boston UniversityORCID 0000-0001-5877-922XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Angela HoiD· 4 shared Sabrina A. KistleriD· 3 shared Gavin D. LaganiiD· 2 shared Adam Thomas LabadorfiD· 1 shared Andressa Mota· 1 shared Andrew EmiliiD· 1 shared Anna NatrakuliD· 1 shared Christian R. O. BartlingiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Angela HoORCID

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Author profile →

4 papers

Recent·Most cited

Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development

Gavin D. Lagani, Mingqi Sha, Weiwei Lin, Sahana Natarajan, Marcus Kankkunen, Sabrina A. Kistler, Noah M. Lampl, Hannah K. Waxman, Evelyn R. Harper, Andrew Emili, Uwe Beffert, Angela Ho

This study identifies aldolase A as a novel Reelin effector involved in dendritic development, independent of its glycolytic function.

Journal of Neuroscience · Sep 3, 2024Peer-reviewedNeuroscience

Tight control of the APP-Mint1 interaction in regulating amyloid production

Shawna M. Henry, Sabrina A. Kistler, Gavin D. Lagani, Christian R. O. Bartling, Dennis Özcelik, Vita Sereikaité, Kristian Strømgaard, Uwe Beffert, Angela Ho

This study investigates how altering the APP-Mint1 interaction affects amyloid-beta production and cellular dynamics in neurons.

Brain Research · Jul 25, 2023Peer-reviewedNeuroscience

Heterogeneity of novel APOER2 isoforms specific to Alzheimer disease impact cellular and synaptic states

Christina M. Gallo, Sabrina A. Kistler, Anna Natrakul, Adam Thomas Labadorf, Uwe Beffert, Angela Ho

The paper identifies AD-specific APOER2 isoforms in human brain regions and shows they alter cell surface expression and synaptic function, potentially contributing to AD pathogenesis.

bioRxiv · Jan 12, 2023 · PreprintNeuroscience

Forkhead box R1-mediated stress response linked to a case of human microcephaly and brain atrophy

Andressa Mota, Rui Hong, Sheng-Yong Niu, Féodora L. Bertherat, Lynne A. Wolfe, Christine May Malicdan, Thomas C. Markello, David R. Adams, William Allen Gahl, Christine S. Cheng, Uwe Beffert, Angela Ho

The paper identifies a de novo FOXR1 variant causing microcephaly and brain atrophy by impairing stress response pathways.

bioRxiv · Nov 3, 2020 · PreprintMolecular Biology