Jef Vangheel

The paper shows that cellular timing heterogeneity regulates rigidity transitions in zebrafish embryos by influencing cell cycle length and tissue-wide mechanical states.

The paper develops a 3D mechanical model of C. elegans zygote polarization, showing how nematic cortical structures ensure robust axis alignment during polarization.

The paper integrates biomechanical modeling with imaging data to analyze the mechanics of cell ingression during C. elegans gastrulation, showing apical constriction and coordinated cell divisions drive the process.

This study investigates spheroid fusion dynamics by measuring cell-cell tension and motility, revealing how tissue fluidity and visco-elastic properties influence fusion outcomes.

This study develops a biophysical model integrating osmolarity and biomechanical feedback to explain stress-dependent growth in breast cancer spheroids, revealing a cellular volume checkpoint for mitosis.

This study uses a 3D active foam model to show how cell-cell adhesion and friction influence rigidity transitions in cell monolayers, with implications for tissue mechanics and cancer metastasis.

The paper introduces a method to infer forces from microscopy images of C. elegans embryos, validated by laser ablation, to study morphogenesis.