Elizabeth A. Kiernan

Multi-omics in the All Of Us Research Program expands mapping genetic mechanisms in health and disease

The paper reports on the All of Us multi-omics cohort, identifying 182,246 QTLs and demonstrating rare variant effects across proteomic and transcriptomic data.

The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain

The paper describes the Neuroscience Multi-Omic Archive, a repository for single-cell transcriptomic and epigenomic data from mammalian brains, providing tools for data access and analysis.

The BRAIN Initiative Cell Census Data Ecosystem: A User's Guide

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

Deploying genomics workflows on high performance computing (HPC) platforms: storage, memory, and compute considerations

This paper provides infrastructure recommendations for optimizing genomics workflows on HPC platforms through benchmarking and profiling.

Inverting the model of genomics data sharing with the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)

The paper describes AnVIL, a cloud-based platform that enables genomic data analysis without data transfer, improving security, scalability, and collaboration.

Prior hypoxia exposure enhances murine microglial inflammatory gene expression in vitro without concomitant H3K4me3 enrichment

This study shows that prior hypoxia exposure increases microglial inflammatory gene expression in response to LPS without increasing H3K4me3 at these genes.