Wail Ba-Alawi

The paper reports on the All of Us multi-omics cohort, identifying 182,246 QTLs and demonstrating rare variant effects across proteomic and transcriptomic data.

The paper develops reproducible pharmacogenomic analysis pipelines using Common Workflow Language to process breast cancer datasets and share them with a Digital Object Identifier.

The paper presents a large-scale cancer pharmacogenomic screen with 11,576 experiments on 910 drug combinations across 85 cancer cell lines, enabling crowd-sourced prediction of synergistic drug pairs and biomarkers.

The paper develops Xeva, an open-source tool for analyzing PDX pharmacogenomic data, finding that few genes and pathways show passage-specific changes.

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

PharmacoDB integrates large pharmacogenomic studies to enable comparison and analysis of drug screening data by curating identifiers and standardizing drug response metrics.