Author

Malcolm D. Walkinshaw

University of EdinburghORCID 0000-0001-5955-9325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Adrian Peter BirdiD· 1 shared Antonia S. J. S. MeyiD· 1 shared Aysima HacisuleymaniD· 1 shared Bernard H. Ramsahoye· 1 shared Christian SeiseriD· 1 shared Chuan HeiD· 1 shared Dina DeSousa· 1 shared Gabriele SchweikertiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperMolecular Biology

Adrian Peter BirdORCID

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3 papers

Recent·Most cited

BiochemistryeLifePeer-reviewedAug 21, 2024

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

Joar Esteban Pinto Torres, Mathieu Claes, Rik Hendrickx…·Yann G.‐J. Sterckx

This study identifies a camelid single-domain antibody that allosterically inhibits trypanosomatid pyruvate kinases, reducing parasite growth.

6 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiophysicsbioRxivPreprintOct 10, 2018

Allosteric effects in catalytic impaired variants of the enzyme cyclophilin A may be explained by changes in nano-microsecond time scale motions

Pattama Wapeesittipan, Antonia S. J. S. Mey, Malcolm D. Walkinshaw, Julien Michel

This study uses MD simulations to show that catalytic impairment in CypA mutants is linked to faster nano-microsecond motions of Phe113, challenging the role of millisecond-scale conformational changes in allosteric effects.

DOI 10.1101/224329

mechanistic / dynamical modelchromatin & epigenetic regulation

𝕏 PostBluesky

Molecular BiologyPLoS GeneticsPeer-reviewedMay 12, 2017

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain

Sabine Lagger, John C. Connelly, Gabriele Schweikert…·Adrian Peter Bird

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.

146 citationstop 1%

mouseDNA methylation

𝕏 PostBluesky