Elizabeth H. Kellogg

This study determines how the I-F3 CRISPR-associated transposase recognizes and pairs transposon ends for transposition using cryo-EM and biochemical analyses.

This study determines the structure of the VchCAST holo integration complex using cryo-EM, revealing conformational licensing mechanisms for RNA-guided DNA integration.

This paper introduces NovoCAST, a new RNA-guided transposon system designed through computational protein design, enabling efficient and programmable DNA integration in human cells.

This paper trains a genomic language model on metagenomic data to predict protein co-regulation and function by learning latent relationships in genomic context.

This study identifies two mobilization pathways in type V-K CASTs and shows how manipulating TnsC availability can increase their specificity to 98.1%.

The paper uses cryo-EM to reveal how TnsC regulates target-site selection in CRISPR-associated transposition systems by transferring polarity information to the transposase.

The paper uses cryo-EM to determine the atomic structure of tau-tubulin interactions, revealing how tau stabilizes microtubules through specific binding sites.