Catherine Vilchèze

The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.

This paper develops a BSL-2-compatible intravital imaging protocol to visualize early Mycobacterium tuberculosis interactions with murine lung macrophages in real time.

This study shows that deleting the ESX-5 secretion system in Mycobacterium tuberculosis reduces ESX-5 substrate secretion, increases ESX-1 substrates, decreases ESX-3 expression, and alters cell morphology and antibiotic susceptibility.

This paper investigates a novel tuberculosis vaccine strategy using a triple auxotrophic Mtb strain, showing intravenous immunization provides superior protection compared to subcutaneous BCG in mice.