Author

Courtney Schill

Johns Hopkins UniversityORCID 0000-0002-2841-7612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benjamin N. KoleskeiD· 2 shared Manish Kumar GuptaiD· 2 shared Rajagopalan SaranathaniD· 2 shared William R. BishaiiD· 2 shared William R. JacobsiD· 2 shared Yazmin B. Martinez-MartineziD· 2 shared Alexander BergiD· 1 shared Catherine VilchèzeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

Benjamin N. KoleskeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Contribution of the novel oxazolidinone TBD09 (MK-7762) to regimens with bedaquiline and pretomanid in a mouse model of tuberculosis

Deepak V. Almeida, Paul J. Converse, Courtney Schill, Jin I. Lee, Micha Levi, Alexander Berg, Mdluli Khisi, Eric L. Nuermberger

This study evaluates TBD09's contribution to BPa-based tuberculosis regimens in mice, showing comparable bactericidal and sterilizing activity to linezolid with reduced toxicity.

bioRxiv · Sep 24, 2026 · PreprintMicrobiology

Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Benjamin N. Koleske, Rajagopalan Saranathan, Courtney Schill, Shichun Lun, Catherine Vilchèze, Lahari Das, Manish Kumar Gupta, Yazmin B. Martinez-Martinez, William R. Bishai, William R. Jacobs

This study shows that deleting the ESX-5 secretion system in Mycobacterium tuberculosis reduces ESX-5 substrate secretion, increases ESX-1 substrates, decreases ESX-3 expression, and alters cell morphology and antibiotic susceptibility.

Proceedings of the National Academy of Sciences · Sep 3, 2025Peer-reviewedMicrobiology

Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis Lineage 2

Benjamin N. Koleske, Courtney Schill, Rajagopalan Saranathan, Somnath Shee, Yazmin B. Martinez-Martinez, Manish Kumar Gupta, Jessica Shen, William R. Jacobs, William R. Bishai

This study shows that loss of the PPE71-38 locus in Mycobacterium tuberculosis Lineage 2 increases stress response gene expression and triglyceride levels, contributing to hypervirulence.

Science Advances · Jul 2, 2025Peer-reviewedMicrobiology