Author

Tianyan Liu

Peking UniversityORCID 0000-0003-1982-2736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mengling ZhangiD· 2 shared Zhixing CheniD· 2 shared Anaïs BadoualiD· 1 shared Bo WangiD· 1 shared Cesar Augusto Valades‐CruziD· 1 shared Charles Kervrann AiD· 1 shared Cheng Li· 1 shared Dongyi XuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Mengling ZhangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

Mengling Zhang, Wenxue Zhao, Zhiguang Xiao, Lei Chang, Xing Wang, Yichen Bai, Xiaodong Guan, Tianyan Liu, Zhaoru Zhang, Yan Li, Qing Li, Cheng Li, Dongyi Xu, Qian Peter Su, Yujie Sun

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

Cell Reports · Mar 1, 2026Peer-reviewedBiophysics

A Palette of Bridged Bicycle-Strengthened Fluorophores

Junwei Zhang, Kecheng Zhang, Kui Wang, Bo Wang, Siyan Zhu, Hongping Qian, Yumiao Ma, Mengling Zhang, Tianyan Liu, Peng Chen, Yuan Shen, Yunzhe Fu, Shilin Fang, Xinxin Zhang, Peng Zou, , Zhixing Chen

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

Nature Methods · May 19, 2025Peer-reviewedBiophysics

DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images

Salomé Papereux, Ludovic Leconte, Cesar Augusto Valades‐Cruz, Tianyan Liu, Julien Dumont, Zhixing Chen, Jean Salamero, Charles Kervrann A, Anaïs Badoual

DeepCristae restores mitochondria cristae in low-resolution microscopy images using a CNN trained on STED data and specialized loss functions.

Communications Biology · Feb 26, 2025Peer-reviewedBioinformatics