Author

Rohit Prakash

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-5981-8980Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Maria JasiniD· 3 shared André NussenzweigiD· 1 shared Andrea DegasperiiD· 1 shared Andrew N.J. TuttiD· 1 shared Brett TayloriD· 1 shared Carla M. C. AbreuiD· 1 shared Cherif BadjaiD· 1 shared Ching Chiek KohiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Maria JasinORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintMay 29, 2026

Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications

Salome Jingchen Zhao, Ching Chiek Koh, Rachel Brough…·Serena Nik‐Zainal

The paper shows HRd is a continuum with functional and mutational heterogeneity, highlighting the need for refined molecular classification for precision interventions.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedJul 12, 2021

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex

Rohit Prakash, Thomas Sandoval, Florian Morati…·Maria Jasin

This study identifies the SWS1-SWSAP1-SPIDR complex as a regulator of distinct homologous recombination pathways, with specific roles in inter-homolog HDR and cancer-related genomic instability.

50 citations

mouseexperimental assay

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GeneticsbioRxivPreprintDec 22, 2017

Shu complex SWS1-SWSAP1 is required for mouse meiotic recombination in concert with the BRCA2 C terminus

Carla M. C. Abreu, Rohit Prakash, Peter J. Romanienko…·Maria Jasin

This study shows that the mouse SWS1-SWSAP1 complex is essential for meiotic recombination by promoting RAD51 and DMC1 focus formation, with BRCA2 C terminus playing a modulatory role.

DOI 10.1101/238196

mouseexperimental assay

𝕏 PostBluesky