Serena Spudich

This study uses single-nucleus multiome sequencing to identify HIV-associated transcriptional and epigenetic changes in brain regions of individuals with HIV, revealing altered glial cell states and pro-inflammatory signaling.

The paper measures CSF proteins in HIV-1 infected and uninfected individuals, identifying patterns of protein changes associated with CNS injury and treatment effects.

The paper uses group based trajectory modeling to identify distinct cognitive phenotypes in children with perinatal HIV and finds demographic factors, not HIV-related variables, are associated with lower cognitive trajectories.