Junchen Yang

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

DiCoLo detects localized differential gene co-expression without clustering or cross-condition alignment, revealing coordinated gene programs in mouse hair follicle development.

This study uses single-nucleus multiome sequencing to identify HIV-associated transcriptional and epigenetic changes in brain regions of individuals with HIV, revealing altered glial cell states and pro-inflammatory signaling.

BiPCA improves PCA for omics count data by adaptively rescaling noise, enhancing biological interpretation and reducing batch effects across multiple modalities.

The paper identifies cell-to-cell communication between mesothelial cells and alveolar tuft cells that regulates lung regeneration after pneumonectomy.

NICHES visualizes cell-cell interactions at the single-cell level using ligand-receptor signaling proxies, enabling analysis of heterogeneous signaling across cell clusters and spatial contexts.

Connectome quantifies and visualizes cell-cell signaling networks from single-cell RNA-sequencing data using a software package for R.