Meei‐Hua Lin

This study evaluates genetic testing outcomes for kidney disease, finding 34% of patients had pathogenic variants, 52% had variants of uncertain significance (VUS), and multidisciplinary review with biobank data helped reclassify some VUS.

The paper shows that laminin-2 in the kidney glomerular basement membrane comes from circulating sources, not local cells, and that BM integrity affects this trans-tissue deposition.